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Research Interests

Molecular pathology

Modern biomedical research has already reached the level of molecular cells. Humans are not only looking forward to a comprehensive understanding of every life phenomenon within cells and among cell populations, but also trying to reveal the molecular mechanisms of cell function exertion and regulation under physiological and pathological conditions. As a basic frontier discipline, research breakthroughs in molecular cell biology have important technical support and theoretical guidance significance for revealing the mechanism of disease occurrence and subsequent medical intervention. Since its establishment in 2001, the School of Medicine of Tsinghua University has attached great importance to the discipline construction and personnel training of molecular cell biology. Over the past 15 years of development, it has established 20 internationally competitive laboratories. The research direction of the laboratory involves membrane proteins and cell signal transduction, epigenetics and tumors, damage repair and splicing, stem cells and regenerative medicine. Disciplinary research adopts a number of world-leading technical methods, including cryo-transmission electron microscopy, X-ray crystallography, ultra-high resolution microscopy imaging, deep sequencing, genome editing, and functional mass spectrometry, etc., working together to reveal the essence of related life phenomena and the molecular and cellular mechanisms of disease occurrence. Especially in recent years, the research on molecular cell biology of Tsinghua University School of Medicine has made a number of major advances in succession. The research results have been published in a series of top international journals such as Nature, Cell, and Science, which have attracted widespread international attention. Tsinghua University School of Medicine is committed to developing into a world-class biomedical research institution and cultivating biomedical research talents with international perspectives and international competitiveness. In the future, focusing on human health and health, the School of Molecular Cell Biology will further explore the originality of disciplines, broaden the disciplines, strengthen basic research and development, and promote the transformation of results, in order to further enhance the international competitiveness of Tsinghua University's life sciences and cultivate more high standards. Leading talents provide the most powerful and solid guarantee.

Regeneration and Aging

Focus on pluripotency and self-renewal and differentiation of adult stem cells, the regulation mechanism of organ development, regeneration and aging, and the application of technology to control cell fate and interfere with aging. In 2021, the population over 60 years old in my country has reached 18.7%, and aging-related diseases will increase year by year and become a major medical burden and challenge. The aging of human cells, tissues and organs causes various functional degenerative diseases, such as decreased fertility, metabolic disorders, and neurodegenerative diseases. At present, the medical field is actively using regenerative medicine to develop treatment plans to repair the body's aging-related diseases. Regenerative medicine covers cell, tissue, organ transplantation and treatment, and combines cross-transformation application fields such as bioengineering and material engineering. School of Medicine, Tsinghua University takes advantage of Tsinghua University's interdisciplinary and fusion advantages, starting from basic medical research, in-depth exploration of the mechanism of stem cell development and regenerative medicine, while establishing basic theories, it also develops treatments for aging-related diseases. The Stem Cell and Regenerative Medicine Center of Tsinghua University was established in 2011. In recent years, the research team has clarified the epigenetic regulation mechanism of stem cells, the mechanism of stem cell and reproductive development, the differentiation mechanism of mesoderm and blood stem cells, and the development and differentiation of neural stem cells. In recent years, we have conducted regular academic exchanges and multidisciplinary cooperation with teams researching stem cells and regenerative medicine in multiple departments and departments to promote research from basic to transformational and clinical applications. In the future development, the medical school will strengthen the integration of medicine and work, interdisciplinary, continue to recruit world-class regenerative medicine experts, and focus on establishing regenerative medicine methods and application platforms for the treatment of aging-related diseases.

Oncology

Malignant tumors are a major disease in my country, with frequent occurrences and a high fatality rate. The annual number of cancer incidences has exceeded 2.5 million, and the deaths have exceeded 1.4 million. It has become a major disease that seriously endangers the health of the people. In recent years, tumor biology research has made great progress, but the research on the mechanism of tumor occurrence and metastasis and anti-tumor treatment still needs to be broken. Biological sciences) as a key development direction: to understand the characteristics and laws of tumor biology, especially to clarify various molecular events and their regulatory mechanisms in the development and development of tumors, and then to find ideal diagnostic techniques and design effective treatment methods. In the direction of tumor biology, the medical school has begun to take shape, with frequent scientific research results, and it has reached the international level in terms of platform hardware facilities. In the next 5 years, Tsinghua will continue to recruit world-class tumor biologists, strengthen the strategy of research base and team cooperation; focus on the construction of tumorigenesis and metastasis mechanisms, tumor genomics and epigenetics, tumor animal models And other research directions; cooperate with Tsinghua University Institute of Immunology, Stem Cell and Regenerative Medicine Center, and various affiliated hospitals of Tsinghua University to promote the combination of basic research and clinical diagnosis and treatment, and seek more clinical partners to establish a joint translational medicine research center. And actively through extensive cooperation with the medical field to transform research results.

Immunology

The human immune system protects the body against a variety of pathogens, ensuring that we can survive and develop in a complex and changeable environment. However, the overreaction of the immune system can lead to many diseases such as inflammatory factor storms, allergies and autoimmune diseases. In recent years, clinical treatments using immune cells to fight cancer have been successful. The Institute of Immunology of Tsinghua University was established in 2014 and currently has 15 laboratories, mainly conducting cutting-edge research related to immune response and immune diseases. The research direction of the laboratory involves many fields of immunology, including the development of the immune system and immune cells, autoimmune diseases, inflammatory diseases, infection immunity, tumor immunity and the physiological and pathological basis and translational research. The laboratory pays attention to the cell development, activation, function of various immune cell types, including T cells, B cells, dendritic cells, macrophages, NK cells, natural lymphocytes, and important roles and biological mechanisms in diseases. Research uses a variety of methods, including disease models, dynamic cell biology, molecular biology and biochemistry, etc., and is committed to revealing related diseases in tissues, cells, intracellular signal transduction, transcription regulation, epigenetics, etc. Based on the molecular mechanism of the disease, we will further develop diagnosis and treatment methods and new drugs for immune-related diseases. The Institute of Immunology of Tsinghua University is committed to developing into a leading immunology research center in China and even Asia, and cultivating a new generation of leading talents for the basic and transformational research of immunology. In the next five years, the Institute of Immunology will further expand the research direction, expand the scale to 20 laboratories, and build more advanced and complete infrastructure to provide comprehensive support for more in-depth and comprehensive immunological foundation and translational research.

Infectious Diseases

Infectious diseases are still an important biological factor threatening our public health, national economy, social stability and national security. In contrast, the scientific and technological level of infectious disease prevention and control in my country is still far behind that of developed countries. The bottleneck of the scientific and technological level has caused us to focus on the hardware related to the prevention and control of infectious diseases (such as medical equipment, drugs, vaccines, diagnostic reagents, etc.) and Software (key hardware manufacturing technology, public health management and emergency management technology, etc.) rely heavily on developed countries in science and technology. The establishment of the "Tsinghua University AIDS Comprehensive Research Center" in 2008 marked the beginning of the infectious disease discipline of Tsinghua University. Since then, relying on the medical school, it has successively introduced a group of talents with international competitiveness in this discipline, and established the "Infectious Disease Research Center of Tsinghua University School of Medicine" in 2013. At present, the center has 6 laboratories, mainly discussing the pathogenic mechanism of bacterial and viral pathogens and the prevention and control methods of related diseases. Research directions include: 1) Research on the etiology and prevention and control technology of bacterial diseases (Zhang Jingren, Babak Javid), 2) Research on the etiology and prevention and control technology of viral infectious diseases (Zhang Linqi, Cheng Gong, Tan Xu), 3 ) Research on the structural biology of pathogens and related biological macromolecules (Xiang Ye). In addition, there are professors from other departments of Tsinghua University who are engaged in research related to the prevention and control of infectious diseases, including: Rao Zihe (Pathogen Structural Biology), Cheng Jing (Infectious Disease Chip Diagnosis Technology), Liu Gang (Medicinal Chemistry) , Deng Haiteng (Protein and Metabolomics), Tang Yefeng (Natural Medicine Chemistry), Chen Yinghua (AIDS Immunization and Vaccines), Wang Xinquan (Pathogen and Immune Macromolecular Structure), Zhu Ting (Pathogen Genomics), Liu Lei (Antiviral Pharmaceutical Chemistry) ). In recent years, our school has also established important facilities related to infectious disease research, including a biosafety secondary laboratory animal platform, a protein testing platform, and a small molecule drug screening platform. At present, our university is preparing to build a biosafety three-level laboratory platform, aiming to improve our university's basic conditions for researching major infectious diseases in my country. Initially formed an influential research force at home and abroad.

Neural engineering

Neuroengineering is an interdisciplinary subject of modern neuroscience, electronics and information science; it is committed to understanding the neural mechanisms behind biological intelligence, providing new ideas for the next generation of artificial intelligence algorithms, and providing new methods and methods for the diagnosis, treatment and rehabilitation of neurological diseases. New platform. The neuroengineering discipline of the Department of Biomedical Engineering has achieved internationally leading research results in brain-computer interface and other areas. It has established a brain-computer interface database platform that supports domestic and foreign research, and has hosted many international and domestic brain-computer interface competitions. In recent years, the frontier research has been continuously promoted in the direction of auditory language neural information decoding, neural information processing loop mechanisms, and brain-like computing, and has been highly praised by international colleagues.

Micro-Nano Medicine and Tissue Engineering

Micro-nano medicine and tissue engineering are the intersection of modern life sciences, medicine and micro-nano technology. It is committed to the development of new platforms such as biochips, sensors, biomedical materials, and bionic artificial tissues for the personalized prediction, prevention, diagnosis and treatment of major diseases. , New methods and new technologies. In recent years, a number of representative research results have emerged in the discipline, including: taking the lead in creating and promoting deafness genetic diagnosis chips in the world, making China the world's largest genetic screening country for genetic diseases and leading the development of the genetic diagnosis industry; Since the COVID-19 pandemic, a series of achievements have been developed, such as the "Six Respiratory Virus Nucleic Acid Detection Kits", "Digital PCR New Coronavirus Hypersensitivity Kits", and "Home-use Integrated Self-service Novel Coronavirus Nucleic Acid Detection Cartridges", etc., effectively assisting the fight against the epidemic Tackling tough problems; for the diagnosis and treatment of major diseases such as tumors and fibrosis, we developed the world's first tissue engineering 3D micro-scaffold that obtained the qualification of medical dressing from the China Food and Drug Administration, the first variable conductivity, self-healing, ultra-light, multi-functional liquid Metal flexible electronic devices, polymer protein-coupled nano-drugs for original tumor targeted therapy, etc.

Medical Imaging

Medical imaging is one of the important research directions of the biomedical engineering discipline of Tsinghua University. This direction is oriented to key issues and clinical needs in the diagnosis, treatment and prevention of major diseases such as cardiovascular and cerebrovascular diseases and tumors. It is at the forefront of imaging methods such as ultrasound, magnetic resonance, PET/CT, image reconstruction, post-processing, and artificial intelligence analysis. Research and promote the scientific and technological research and industrial transformation of the core components, software and hardware systems of my country's large-scale high-end medical imaging equipment, committed to achieving independent and controllable key core technologies, and establishing imaging specifications and quality control through the entire process of new technology research and development and application transformation Standard and clinical solutions. This direction is based on real-time dynamic multi-mode medical imaging methods, and through the development of innovative interventional instruments and surgical robots, new methods and new systems for precise navigation of minimally invasive diagnosis and treatment are established to realize the integration of intelligent diagnosis and treatment.

Medical equipment

The medical instrument direction of the Department of Biomedical Engineering, School of Medicine, Tsinghua University, mainly includes the research content of smart instruments and medical equipment. This direction mainly focuses on the scientific instruments in the domestic scientific research field and the high-end medical equipment in the clinical field. Difficult, expensive to see a doctor!” and other major social demand issues, we will actively explore innovative technologies related to biomedical testing from multiple levels of molecules-tissues, cells-organs-small animals-humans, and develop intelligent advanced scientific instruments and high-end innovations. Medical equipment, obtained the national CFDA medical device product registration certificate and the EU CE certificate, etc., realized industrial transformation, carried out clinical demonstration and large-scale promotion and application, and met the actual needs of healthy China's biomedical frontier scientific research, clinical medical treatment, health and epidemic prevention. The specific research content includes five aspects: 1. Precision medicine molecular diagnostic technology and medical instrument research; 2. New biosensing technology and super-resolution measurement system research; 3. In-vivo imaging technology and multi-modal molecular imaging equipment research; 4. 5. Research on wearable physiological sensing technology and human health monitoring system; 5. Research on precision technology of traditional Chinese medicine and artificial intelligence health analysis system.